Numab Therapeutics to receive additIonal CHF 260M from its Japanese partner


Numab Therapeutics and the Japanese based Ono Pharmaceutical have extended their relationship by executing another research and option agreement to discover and develop a multi-specific antibody drug candidate for the treatment of various cancers. Ono will again pay to Numab up to CHF 260 million in upfront and milestone payments.



The Zurich based Numab Therapeutics is focusing on the development of multi-specific antibodies based on its proprietary MATCH technology platform for the treatment of several cancers. The company’s lead oncology program ND021 was designed to balance potent anti-tumour immunity with a desirable safety profile by targeting 4-1BB, PD-L1 and Human Serum Albumin simultaneously.

In March 2017, Numab entered a research and option agreement with Ono Pharmaceutical Co., Ltd. for the identification of a multi-specific antibody candidate for development in immuno-oncology. Today, the two companies announced the expansion of their relationship. Similar to their earlier collaboration initiated in 2017, under the new agreement, Ono has obtained an option to acquire from Numab exclusive rights to develop and commercialize an immuno-oncology drug candidate that will leverage Numab’s platform technology in order to actualize one of Ono’s novel therapeutic approaches. In exchange, Ono will pay to Numab up to CHF 260 million in upfront and milestone payments plus tiered single to double-digit royalties on sales.

“Today’s announcement signals a mutual recognition of the quality and expertise that both parties have contributed under our earlier, ongoing agreement. Ono’s decision to enter another agreement based on Numab’s technology is a clear validation of our platform and highlights their commitment to include multi-specific antibodies as a major component of their pipeline strategy in oncology,” commented Oliver Middendorp, Chief Business Officer of Numab Therapeutics. “In addition to ND023, which was initiated under our original agreement, we are excited to collaborate with Ono on yet another truly differentiated mechanism of action with this new project.”

Numab has ongoing relationships with a number of pharmaceutical companies including 3SBio / Sunshine Guojian, Eisai Co., Ltd., CStone Pharmaceuticals, Ono Pharmaceutical Co., Ltd., Kaken Pharmaceutical Co., Ltd., and Tillotts Pharma AG. Since its foundation, Numab has generated revenues in excess of CHF 50 million through partnering activities.

 (Press release)